Intraventricular vancomycin in the treatment of ventriculitis associated with cerebrospinal fluid shunting and drainage.
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Intraventricular vancomycin in the treatment of ventriculitis associated with cerebrospinal fluid shunting and drainage.
The results of treatment of 50 cases of ventriculitis associated with the use of cerebrospinal fluid shunts or external ventricular drains, and treated with intraventricular vancomycin, are reported. While the overall cure rate was 66% with four cases lost to follow-up, in those cases where treatment involved shunt removal, 20 mg vancomycin daily intraventricularly, and another appropriate syst...
متن کاملCerebrospinal fluid (CSF) pharmacokinetics of intraventricular vancomycin in patients with staphylococcal ventriculitis associated with external CSF drainage.
We studied the efficacy and pharmacokinetics of intraventricularly administered vancomycin in three patients with shunt-associated staphylococcal ventriculitis. We instilled 10 mg of the drug intraventricularly every 24 hours. Cerebrospinal fluid (CSF) levels were measured 1 hour after instillation and then every 2 hours. Peak vancomycin levels reached a mean of 292.9 microg/mL. The mean trough...
متن کاملCerebrospinal fluid physiology and cerebrospinal fluid drainage.
To the Editor:—We read with interest the article of Conzen et al. demonstrating a reduction of cardiac troponin I release after coronary artery bypass grafting on the beating heart when sevoflurane was compared to propofol. Most previous studies identified peak postoperative troponin I as the major endpoint. It is not clear from the article of Conzen et al. which was the peak postoperative trop...
متن کاملCerebrospinal Fluid Physiology and Cerebrospinal Fluid Drainage
To the Editor:—We read with interest the article of Conzen et al. demonstrating a reduction of cardiac troponin I release after coronary artery bypass grafting on the beating heart when sevoflurane was compared to propofol. Most previous studies identified peak postoperative troponin I as the major endpoint. It is not clear from the article of Conzen et al. which was the peak postoperative trop...
متن کاملConcentrations of fosfomycin in the cerebrospinal fluid of neurointensive care patients with ventriculostomy-associated ventriculitis.
OBJECTIVE The present study was performed to test the ability of fosfomycin to penetrate into the CSF of neurointensive care patients with ventriculostomy-associated ventriculitis. PATIENTS AND METHODS Six patients requiring neurointensive care monitoring, including extraventricular drainage due to secondary obstructive hydrocephalus, were enrolled into the study. All patients received 8 g of...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1987
ISSN: 0022-3050
DOI: 10.1136/jnnp.50.11.1419